We have the 05 228 with the F225. I have ZERO complaints. Yes, we DO trailer and I take advantage of that when buying gas. The 225 takes 87 octane and the 250 requires 89 octane.
As to performance, the GW posted specs are pretty close. With full fuel (we have the aux tank - 148 gals total), all the fishing gear, 100-plus lbs of ice, curtains installed, 3 adults on board, we can get 38 to 39 MPH top end. Quite frankly, I dont go that fast and sea conditions normally dont permit over a 25 to 30 MPH cruise anyway, plus I want to go easy on the fuel burn. I think the F250 would get us maybe 3 MPH extra on the top end and slightly better torque in the mid-range. Either way its pretty much a 40 MPH rig, give or take a couple of mph.
If I was totally water-bound and stuck with marina fuel, Id go ahead with the F250. If trailering, the F225 is still a viable alternative.