In reality, you need to experiment, not sure how your boat will run the best, but with most Grady's, running the main tank full and only filling the aux when needed is how the boat was designed to be operated. In most cases this is the optimal way for performance numbers except on the 22 seafarer where tanks were actually changed over time to switch locations. If you make long trips, I'd run off your aux first since that will give you your worst results, then save the main for after, burning the other way will be worse on most models. I would advise against using both tanks at the same time, I've seen guys run out of gas doing so, it is much harder to manage your fuel and since the tanks are not the same size and may not be fueled the same, that can lead to problems, and will also involve more monitoring for you. I will leave about 1/3 tank in my aux at all times, and maybe once every 5 trips I will fill it more and run the tank just so the gas does not sit, but my main tank is always over 1/3 or full. I found my 265 express operates with way better this way, and from most other Grady's I've been on, running the main full and the aux with less fuel has provided better efficiency. For the sheer fact of having to manage two tanks at the same time, I would avoid running one engine off each tank. I use the Yamaha fuel management a lot, I always monitor my mpg so I can optimize my performance. I also will fill my main tank, and when I am about 15-20gal from being empty I switch to my other tank on long runs, that way I never run the tank down all the way unless absolutely necessary in an emergency. Like I said, main should give the best results, but if the boat has been rigged with after market parts or re powered engines that can alter the performance, I'd experiment on tank levels and see how the boat runs. Maybe fill both tanks then run the aux out and see how the mpg and fuel burn changes as the tank gets burned off, chances are it should improve as the tank empties. Do the same for the other tank. Also, use the same method for trimming the boat out, as I come on plane for the first time I trim my engines all the way down, once you reach your speed you want to cruise at or close to it, trim the engines up while monitoring the fuel management gauge, it will begin to increase your rpm's and give a more efficient mpg and burn rate. Once you see those numbers change for the worst, trim the engine down a hair and leave her. If it is rough at, you may need to trim them a little lower and sacrifice efficiency to keep the engines from ventilating. Most Grady's like to run with the engines trimmed out high, but that all depends on how the boat is loaded and the sea conditions. Enjoy the new boat and let us know what your results are after you run the tanks in various configurations.