I also own a Taurus SHO with Eco-boost, I agree they do not sip fuel as advertised...
Back to the original question, I used to own a 92 Explorer with hardtop, dual tanks, etc. I repowered in late 1999 with a 2000 250 OX66 that was mounted on the factory bracket. I used to burn about 7gph at 7knots trolling offshore, burned about 3gph at 2knots trolling for striped bass, burned about 14gph cruising at 25knots, and burned about 27gph at wot (38knots). Best I ever saw cruising was lightly loaded (two people and only twenty gallons of fuel) was 2.5 statute mpg. We ran to the canyons here in NJ several times when the conditions allowed, we would burn between 130 and 155 gallons per trip. I used to bring extra fuel with us, yes it was dangerous, but I was a little younger. By the way the NJ canyons are about 90 statute miles from my inlet.
I now own a 20006 Marlin with twin F250 engines. Trolling for bass we burn between 2 and 3gph, trolling for tuna we burn betweeen 3 and 4gph depending on seas and speed, cruising and wot are significantly higher as we actually start to use all those ponies. Best we see at cruise is 1.5 statute mpg.
My point is that while the 250Ox66 is a reliable motor on most accounts, I would not call it thrifty by any means. I would suspect a new F250 or even F300 would cut the trolling fuel consumption in half (yes literally in half). I also suspect the cruise numbers would be better by about ten or twenty percent. The reason I keep mentioning trolling is because we do a lot of trolling. I have made trips with five guys on the 30 marlin that we actually burned less fuel than we would have with four guys on the 24 Explorer (these were not canyon runs). I have had several trips to the canyon that the outboard(s) did not stop running the entire trip, with the four strokes they sip fuel under light load.