They still make 2 strokes (HPDI, ETEC, Optimax).
2 strokes weigh less, have more low end power, DI 2 strokes will have similar economy at cruise (but at idle they use at least twice as much and carb models will add about 10%), a little less maintenace costs (no timing belt or valves to adjust but when you factor that over 1000 hours it's not that bad), and reliability is a whole paragraph of it's own. For a lifespan, a 2 stroke can go 2000 hours and a 4 stroke, well, more. Now at 100 hours a year usage that's 20 years, I wouldn't trust either at the age.
The less things there are to go wrong, the more reliable it is. The old 2 stroke carburated motors are very simple, take care of them and feed them gas and they'll run. But on a cold morning they're a PIA to get going.
If you're looking at a used boat with old 2 strokes they will run, run and run but are thirsty (gas and oil) and smoke (which may piss off the Admiral) but treat the boat as hull value only. The years and hours are getting up there. DI 2 strokes are more efficient, start easily but still smoke a little. 4 strokes will have the best overall mileage and don't smoke but loose a little punch. The current boat market is tanked. People treat 4 strokes with 500 hours as being "over the hill" so bid accordingly.
If you want to get a new motor and the hull can handle the weight and 225 HP, my first choice would be the new Yamaha 4 stroke. At the 150 HP level the F150, and at 200 HP it's a toss up between 2 and 4 strokes (any manufacturer).
At resale you're going to take a bath no matter which route you take.