I haven't tackled this yet but still have plans to. If anyone with a newer 330 has info on what size thru-hull and seawater pump (and piping) they are running on the boats with dual A/C units, that would be much appreciated. I believe it is a single water pickup but might be wrong on that. The newer boat owner's manual isn't obvious on this.
I also think I figured out how they ran A/C to the head on the newer boats, it looks like when they did away with the rectangular porthole in the aft cabin, they also molded in a chase along that wall. Looks like 4" ductwork would fit through there and it would make sense with the rest of the duct layout. Edit: Duh, yes, found this in the 2016 330 owner's manual.
I still think there is room in the older hull layout to make this work without major surgery, the space behind that tackle drawer in the port side is massive although I do need to double check clearances. In the newer models it should be a piece of cake.