My input on your original questions.
It seems several models of Grady list to port when on the dock. I assume it is galley related, due to the fridge and additional glass for the cabinet, etc. My Marlin also has microwave and AC unit on port side, and batteries too. Tough to offset this weight by just the weight of a toilet and hot water tank. But we all agree that the boat listing to port an inch while tied to the dock is no big deal.
I play with the tabs quite a bit. I don't notice a tilt to port when running, but I'll look for it this summer. Regardless, just tab out of it whichever way it tilts. Differences in wind, tide, speed, direction the waves are hitting the hull, and placement of beers, butts etc. all can effect equilibrium. Sometimes I'll actually tab up and down to cut quartering seas more smoothly. Like the suggestions before, get on plane and find the sweet spot trimming the engines (notice if one engine is trimmed higher than another that will also torque your boat one way or the other....). After the boat is "happy" with your RPM etc... then mess with the tabs, and don't be shy. It's why they are there.
Regarding hole shot, I noticed a minor benefit to hole shot when I switched from 3 blades to 4. More surface area to "grip" the water= less cavitation and more lift. I also noticed with the 4 bladers that I don't need to trim the motors out much. My fuel economy suffered a touch, but I'm in a better spot on the Yamaha torque-curve with my ass-heavy Marlin. Call Ken at Prop Gods to discuss your situation, he will ask you several questions like desired top end, desired fuel burn, etc... and hook you up with a suggestion of 3 blades or 4 and which pitch/diameter to try.
My 2c
Randy