Bates, if you go with the new V6 300, it's the easiest, lowest cost, and existing drive will work fine.
Dropping the hammer on one F350 in a hole shot is no way more force than doing the same on twin F200s as Grady offered in twin setup, and twin F200s are hundreds of pounds heavier than one F350.
The problem of the V8 is not torque nor weight since it weighs less than twins and less HP total than the Gulfstream in twin option.
The problem is a standard drive for a single motor does not span the transom as the twin drive does.
The motor's small motor brackets transfer the forces to the larger Grady Drive in turn transfers the forces to the much larger boat transom where it meets the hull on three sides to push and pull it. The larger the drive span the better.
Since you would need a new drive anyway for the V8 since it's a 6 bolter and has a wider bolt pattern, you have to get a single motor drive manufactured that angles out onto the transom footprint similar as the grady twin drive does. The setback may be more since the V8 is taller, however the gear case still probably will be partially submerged anyway. Most drive manufactures custom design each unit, forget going to the Grady dealer for it. There are several who make drives who you can discuss that with. They run programs to calculate the forces and loading as I would expect.
It is not practical to consider modifying the transom and hull attachment glass layup schedule in a retrofit, in new it is easy.
Like with twin F200 option, the aux gas tank gets nixed or not used if you have one. But if the setback is the same as the Gradydrive for twin F200s, the loading will be way less for a F350 perhaps making the aux tank usable if you have one. And no added stress on the boat hull. Realizing twin F200s are likely counter-rotating, I don't recall seeing counters as a requirement on the boat. Two RH motors will apply more torque than two counters. Counters cancel each other's effect at the common bolting surface.
Good luck.