What you can do first is check weigh gain with the 4 strokes.
Take a photo from the side most level possible and then have some persons with similar or better a bit higher weight standing on the transom and take a second photo just for your records.
This will show you rather correct how much the transom will sink while not moving and show if scuppers and engine bracket get submerged.
Mark a sign at float level with the added weight this will help later as below.
Should it be a lot then you may to a running test but in this case obviously without people standing on the transom,
use for example plastic barrels filled with water near the transom to have transom sink at same depth.
Once you filled the barrels with water till the transom is at same depth run her as you usually do and check for odd behavior.
Biggest problem is often gong over the hump as the lower transom creates a odd water flow to the outboard leading to ventilation issues and without trim tabs she may sliding on her butt instead of getting it up.
If this is the case (as I had on several boats, but not on a GW) then you need first see if you can shift weight bow wards to counterbalance, use more trim tabs and/or a stern lifting propeller.
However, moving from single two stroke to single 4 stroke is not necessarily a problem as modern 4 strokes are not that more heavy as 2 strokes, its more complicated with twins.
Chris