Years ago (like 6?) I converted from 3 blade to 4 blades on my then F250 powered 330 (2005 TXR's in 3.3L).
Specifically, I went with 4 blade 16" pitch Offshore props by PowerTech.
These props have a 15.25 diameter. For reference, part # OFS416P-CLYX200.
I then repowered to F300's last July. Using the same props on the 300's.
I have been very satisfied with these props on my 330.
The four blade delivered what I was looking for: more torque at the low end and stronger power plowing through swells while cruising. At cruise, I get on average just a tad below 1 statute mile per gallon (or .87 nautical MPG).
Cruise with the F250's was between 22-24 knots. Cruise with the F300's is now 26-28 knots.
Both of the above at 4,300-4,400 RPM's with WOT at 5,600 to 5,800 RPM's.
IMHO, anything over a 16 pitch will lug your engine. I know a guy with an identical 330 as mine with F300's and he has the same 4 blade props as me but in 14 pitch. He is happy with the 14's. I tried a set of 15 pitch 4 blades and didn't like them with the F300's. They seemed to over rev the 300's. Went back to my 4 blade 16's. All good for me now...